Nitric oxide generating systems
AssigneeNOTA Laboratories, LLC
InventorsGlenn Martin, Aurora L. Fernandez DeCastro, Mark E. Meyerhoff
Life of this patent
Estimating the term…
Abstract
An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor/adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.
Claims63
A nitric oxide (NO) generating system, comprising:
- an NO generating formulation, including:
- a stable NO donor/adduct;
- a hydrophilic binder;
- and
- an additive;
- wherein the additive is to control a rate of release of NO from the NO donor/adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light;
- and
- an inhalation device in operative contact with the NO generating formulation.
A nitric oxide (NO) generating system, comprising:
- an NO generating formulation, including:
- a stable NO donor/adduct;
- a hydrophilic binder;
- and
- an alkaline material selected from the group consisting of sodium carbonate, a mixture of sodium carbonate and sodium bicarbonate, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, trisodium phosphate, and combinations thereof;
- wherein the alkaline material renders a pH of the NO generating formulation to be at or above 8.5, thereby destabilizing the NO donor/adduct to liberate NO after the formulation is exposed to an effective amount of water vapor or a hydrating liquid;
- and
- an inhalation device in operative contact with the NO generating formulation.
A nitric oxide (NO) generating system, comprising:
- an NO permeable container including an attachment mechanism;
- and
- an NO generating formulation contained in the NO permeable pouch, the NO generating formulation including a stable NO donor/adduct that is activatable when exposed to an effective amount of water vapor, a hydrating liquid, or blue or ultraviolet (UV) light.
An NO generating system comprising:
- a face mask;
- a housing secured to the face mask, the housing including a reservoir with an NO permeable wall positioned between the housing an interior of the face mask;
- and
- an NO generating formulation contained in or to be introduced into the reservoir, the NO generating formulation including a nitrite salt that is to generate NO when exposed to an effective amount of an acidic buffer.
Dependencies are inferred from the claim text.