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US 2022/0176022 A1Published application
Medical device and method for manufacturing same
AssigneeTerumo Kabushiki Kaisha
InventorMasanori KURAMOTO
Life of this patent
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Abstract
A medical device includes: a substrate layer; an adhesive layer formed on at least a part of the substrate layer and containing a hydrophilic copolymer (1) containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group; and a surface lubricious layer formed on at least a part of the adhesive layer and containing a polymer containing a structural unit derived from acrylamide and a hydrophilic copolymer (2).
Claims20
A medical device, comprising:
- a substrate layer;
- an adhesive layer formed on at least a part of the substrate layer, the adhesive layer containing a hydrophilic copolymer (1) containing (i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- and
- a surface lubricious layer formed on at least a part of the adhesive layer, the surface lubricious layer containing a polymer, said polymer containing (a) a structural unit derived from acrylamide, and (b) a hydrophilic copolymer (2) containing (i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group.
1 more element
A method for manufacturing a medical device comprising:
- applying a coating liquid (1) onto a substrate to form an adhesive layer on the substrate, the coating liquid (1) comprising:
- a hydrophilic copolymer (1) containing:
- i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure;
- ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof;
- and iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- and
- applying a coating liquid (2) onto the adhesive layer to form a surface lubricious layer, the coating liquid (2) comprising a polymer containing:
- (a) a structural unit derived from acrylamide;
- and (b) a hydrophilic copolymer (2), the hydrophilic copolymer (2) containing:
- i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure;
- ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof;
- and iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group.
9 more elements
A method comprising:
- inserting a medical device into a lumen in a living body, the medical device comprising:
- a substrate layer;
- an adhesive layer formed on at least a part of the substrate layer, the adhesive layer containing a hydrophilic copolymer (1) containing (i) a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C) having a photoreactive group;
- and
- a surface lubricious layer formed on at least a part of the adhesive layer, the surface lubricious layer containing a polymer, said polymer containing (a) a structural unit derived from acrylamide, and (b) a hydrophilic copolymer (2) containing (i) a structural unit derived from a polymerizable monomer (A′) having a sulfobetaine structure, (ii) a structural unit derived from a polymerizable monomer (B′) having at least one group selected from the group consisting of a sulfonic acid group, a sulfuric acid group, a sulfurous acid group, and salt groups thereof, and (iii) a structural unit derived from a polymerizable monomer (C′) having a photoreactive group;
- and
- moving the medical device in the lumen in the living body, whereby aqueous liquid in the lumen contacts and wets the surface lubricious layer so that the surface lubricious layer exhibits a lubricating property.
4 more elements
Dependencies are inferred from the claim text.