Platelet-derived growth factor compositions and methods of use thereof
AssigneeBioMimetic Therapeutics, LLC
InventorSamuel E. Lynch
Life of this patent
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Abstract
A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.
Claims21
1-78. (canceled)
An implant material comprising a porous calcium phosphate having incorporated therein a solution comprising platelet derived growth factor (PDGF) having a concentration ranging from about 0.1 mg/mL to about 1.0 mg/mL in a buffer, wherein the calcium phosphate comprises interconnected pores, a porosity greater than 40%, and particles having a size ranging from about 100 microns to about 5000 microns,
- wherein the calcium phosphate is chosen from one or more of tricalcium phosphate, hydroxyapatite, amorphous calcium phosphate, calcium metaphosphate, dicalcium phosphate dihydrate, heptacalcium phosphate, calcium pyrophosphate dihydrate, calcium pyrophosphate, and octacalcium phosphate, and
- wherein the implant material does not comprise demineralized freeze-dried bone allograft.
An implant material comprising collagen and a porous calcium phosphate having incorporated therein a solution comprising platelet derived growth factor (PDGF) having a concentration ranging from about 0.1 mg/mL to about 1.0 mg/mL in a buffer, wherein the calcium phosphate comprises interconnected pores, a porosity greater than 40%, and particles having a size ranging from about 100 microns to about 3000 microns,
- wherein the calcium phosphate is chosen from one or more of tricalcium phosphate, hydroxyapatite, amorphous calcium phosphate, calcium metaphosphate, dicalcium phosphate dihydrate, heptacalcium phosphate, calcium pyrophosphate dihydrate, calcium pyrophosphate, and octacalcium phosphate, and
- wherein the implant material does not comprise demineralized freeze-dried bone allograft.
Dependencies are inferred from the claim text.