Functionalized silica nanorings, methods of making same, and uses thereof
AssigneeCornell University
InventorsMelik Z. Turker, Thomas C. Gardinier, Ulrich B. Wiesner
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Abstract
Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for the surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.
Claims50
A silica nanoring defining a single aperture and comprising an outer surface and an inner surface, wherein at least a portion of or substantially all of the outer surface, and optionally, at least a portion of or substantially all of the inner surface, or all of the surfaces of the silica nanoring are functionalized with polyethylene glycol (PEG) groups, functionalized PEG groups, or a combination thereof, and at least a portion of or all the silica matrix of the silica nanoring is microporous.
A method of making silica nanorings comprising
- forming a reaction mixture comprising
- one or more silica precursor(s);
- one or more surfactant(s);
- one or more pore expander(s);
- and
- holding the reaction mixture at a time and temperature, whereby the silica nanorings are formed;
- and
- adding a PEG-silane, PEG-silane conjugate comprising a display group, or a combination thereof to the reaction mixture.
The method 11, further comprising removing substantially all or all of the surfactant(s) and/or pore expander(s) from the interior of the silica nanoring.
Dependencies are inferred from the claim text.