Compounds and methods for the detection of trpv-6 cancers and drug delivery
AssigneeSoricimed Biopharma Inc.
InventorJohn M. STEWART
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Abstract
Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.
Claims39
1-14. (canceled)
A method for detecting TRPV6 protein in a sample comprising:
- a) contacting the sample with the compound comprising a Transient Receptor Potential Vanilloid 6 (TRPV6)-binding peptide conjugated to a biomolecule, wherein the TRPV6-binding peptide comprises all or part of a peptide comprising EGKLSSNDTEGGLCKEFLHPSKVDLPR (SEQ ID NO:1);
- b) detecting the biomolecule conjugated to the TRPV6-binding peptide thereby detecting the TRPV6 protein.
A method of identifying cancer in a sample from a subject comprising:
- a) detecting TRPV6 mRNA or protein in the sample;
- b) comparing the amount of TRPV6 mRNA or protein in the sample with an amount of TRPV6 mRNA or protein in a control sample, wherein an increased amount of TRPV6 mRNA or protein in the sample compared to the control is indicative of cancer.
A method of identifying a cancer tumor in a subject comprising:
- a) administering to the subject a compound comprising a TRPV6-binding peptide or an antibody to TRPV6;
- b) detecting the TRPV6-binding peptide or antibody to TRPV6 in the subject thereby detecting TRPV6;
- c) identifying regions of the subject with increased levels of TRPV6 relative to a control level, wherein increased levels of TRPV6 are indicative of a cancer tumor.
32-37. (canceled)
A compound comprising a Transient Receptor Potential Vanilloid 6 (TRPV6)-binding peptide conjugated to a biomolecule, wherein the TRPV6-binding peptide comprises all or part of a peptide comprising EGKLSSNDTEGGLCKEFLHPSKVDLPR (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.