Neovascular-targeting contrast medium composition and method for preparing same
AssigneeKorea Basic Science Institute
InventorsKi-Yuk CHANG, Chan-Woo KIM, Kwan-Soo HONG, Hyun-Seung LEE, Hyun-Min KIM
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Abstract
The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated αvβ3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.
Claims12
A neovascular-targeting contrast medium composition comprising:
- an αvβ3 integrin targeting nanobody encoded by at least one kind of base sequence selected from a group consisting of base sequences represented by SEQ ID NOs:
- 1 to 10;
- and
- a probe labeled with a radioactive isotope.
A method for preparing a neovascular-targeting contrast medium, the method comprising:
- a step (step 1) of reacting an αvβ3 integrin targeting nanobody encoded by at least one kind of base sequence selected from a group consisting of base sequences represented by SEQ ID NOs:
- 1 to 10 with a probe labeled with a radioactive isotope in a buffer solution at pH 8.0 or higher:
- (wherein in the Reaction Formula 1, each of R1 to R5 represents hydrogen or halogen,
- R6 represents C-11, N-13, O-15, F-18, Ru-82, Ga-68, Cu-60, Cu-61, Cu-62, Cu-64, Cu-67, K-38, Rb-82, Sc-44, I-123, I-124, I-125, Zr-89, Y-86, Y-90, Lu-177, In-111 or Tc-99m).
Dependencies are inferred from the claim text.