Targeting compounds for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines
AssigneeHQ Medical Netherlands B.V.
InventorsMarkwin Hendrik Maring, Carel Jan Vogels
Life of this patent
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Abstract
Systems for use as a medicament for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines, include a targeting molecule for binding necrotic cells, a chelator, and a radionuclide, to a dosage comprising the system. In particular, the systems relate to compositions targeting necrotic cells.
Claims15
A targeting system for use as a drug for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines, the system comprising a targeting molecule for binding to necrotic cells, the targeting molecule being a cyanine selected from HQ4, HQ5, CW-800 and ZW-800, and combinations thereof,
- wherein the cyanine is attached to a chelator, wherein the chelator is selected from DOTA and NOTA, and combinations thereof,
- and attached to the chelator a radionuclide selected from Cu, In, Gd, Ga, Lu, Y, I, and Zr, and combinations thereof.
A targeting system drug for esophagus cancer selected from 64Cuy-DOTA-HQ4, 67Cuy-DOTA-HQ4, 67Gay-DOTA-HQ4, 68Gay-DOTA-HQ4, 70Gay-DOTA-HQ4, 72Gay-DOTA-HQ4, 89Zry-DOTA-HQ4, 90Yy-DOTA-HQ4, 95Zry-DOTA-HQ4, 111Iny-DOTA-HQ4, 114Iny-DOTA-HQ4, 123Iy-DOTA-HQ4, 124Iy-DOTA-HQ4, 153Gdy-DOTA-HQ4, 159Gdy-DOTA-HQ4, 177Luy-DOTA-HQ4, 64Cuy-DOTA-HQ5, 67Cuy-DOTA-HQ5, 67Gay-DOTA-HQ5, 68Gay-DOTA-HQ5, 70Gay-DOTA-HQ5, 72Gay-DOTA-HQ5, 89Zry-DOTA-HQ5, 90Yy-DOTA-HQ5, 95Zry-DOTA-HQ5, 111Iny-DOTA-HQ5, 114Iny-DOTA-HQ5, 123Iy-DOTA-HQ5, 124Iy-DOTA-HQ5, 153Gdy-DOTA-HQ5, 159Gdy-DOTA-HQ5, 177Luy-DOTA-HQ5, 64Cuy-DOTA-CW800, 67Cuy-DOTA-CW800, 67Gay-DOTA-CW800, 68Gay-DOTA-CW800, 70Gay-DOTA-CW800, 72Gay-DOTA-CW800, 89Zry-DOTA-CW800, 90Yy-DOTA-CW800, 95Zry-DOTA-CW800, 11Iny-DOTA-CW800, 114Iny-DOTA-CW800, 123Iy-DOTA-CW800, 124Iy-DOTA-CW800, 153Gdy-DOTA-CW800, 159Gdy-DOTA-CW800, 177Luy-DOTA-CW800, 64Cuy-DOTA-ZW800, 67Cuy-DOTA-ZW800, 67Gay-DOTA-ZW800, 68Gay-DOTA-ZW800, 70Gay-DOTA-ZW800, 72Gay-DOTA-ZW800, 89Zry-DOTA-ZW800, 90Yy-DOTA-ZW800, 95Zry-DOTA-ZW800, 111Iny-DOTA-ZW800, 114Iny-DOTA-ZW800, 123Iy-DOTA-ZW800, 124Iy-DOTA-ZW800, 153Gdy-DOTA-ZW800, 159Gdy-DOTA-ZW800, 177Luy-DOTA-ZW800, 64Cuy-NOTA-HQ4, 67Cuy-NOTA-HQ4, 67Gay-NOTA-HQ4, 68Gay-NOTA-HQ4, 70Gay-NOTA-HQ4, 72Gay-NOTA-HQ4, 89Zry-NOTA-HQ4, 90Yy-NOTA-HQ4, 95Zry-NOTA-HQ4, 111Iny-NOTA-HQ4, 114Iny-NOTA-HQ4, 123Iy-NOTA-HQ4, 124Iy-NOTA-HQ4, 153Gdy-NOTA-HQ4, 159Gdy-NOTA-HQ4, 177Luy-NOTA-HQ4, 64Cuy-NOTA-HQ5, 67Cuy-NOTA-HQ5, 67Gay-NOTA-HQ5, 68Gay-NOTA-HQ5, 70Gay-NOTA-HQ5, 72Gay-NOTA-HQ5, 89Zry-NOTA-HQ5, 90Yy-NOTA-HQ5, 95Zry-NOTA-HQ5, 111Iny-NOTA-HQ5, 114Iny-NOTA-HQ5, 123Iy-NOTA-HQ5, 124Iy-NOTA-HQ5, 153Gdy-NOTA-HQ5, 159Gdy-NOTA-HQ5, 177Luy-NOTA-HQ5, 64Cuy-NOTA-CW800, 67Cuy-NOTA-CW800, 67Gay-NOTA-CW800, 68Gay-NOTA-CW800, 70Gay-NOTA-CW800, 72Gay-NOTA-CW800, 89Zry-NOTA-CW800, 90Yy-NOTA-CW800, 95Zry-NOTA-CW800, 111Iny-NOTA-CW800, 114Iny-NOTA-CW800, 123Iy-NOTA-CW800, 124Iy-NOTA-CW800, 153Gdy-NOTA-CW800, 159Gdy-NOTA-CW800, 177Luy-NOTA-CW800, 64Cuy-NOTA-ZW800, 67Cuy-NOTA-ZW800, 67Gay-NOTA-ZW800, 68Gay-NOTA-ZW800, 70Gay-NOTA-ZW800, 72Gay-NOTA-ZW800, 89Zry-NOTA-ZW800, 90Yy-NOTA-ZW800, 95Zry-NOTA-ZW800, 111Iny-NOTA-ZW800, 114Iny-NOTA-ZW800, 123Iy-NOTA-ZW800, 124Iy-NOTA-ZW800, 153Gdy-NOTA-ZW800, 159Gdy-NOTA-ZW800, 177Luy-NOTA-ZW800, and combinations thereof, wherein ye[1,2,3,4].
A targeting system drug for lung cancer selected from 64Cuy-DOTA-HQ4, 67Cuy-DOTA-HQ4, 67Gay-DOTA-HQ4, 68Gay-DOTA-HQ4, 70Gay-DOTA-HQ4, 72Gay-DOTA-HQ4, 89Zry-DOTA-HQ4, 90Yy-DOTA-HQ4, 95Zry-DOTA-HQ4, 111Iny-DOTA-HQ4, 114Iny-DOTA-HQ4, 123Iy-DOTA-HQ4, 124Iy-DOTA-HQ4, 153Gdy-DOTA-HQ4, 159Gdy-DOTA-HQ4, 177Luy-DOTA-HQ4, 64Cuy-DOTA-HQ5, 67Cuy-DOTA-HQ5, 67Gay-DOTA-HQ5, 68Gay-DOTA-HQ5, 70Gay-DOTA-HQ5, 72Gay-DOTA-HQ5, 89Zry-DOTA-HQ5, 90Yy-DOTA-HQ5, 95Zry-DOTA-HQ5, 111Iny-DOTA-HQ5, 114Iny-DOTA-HQ5, 123Iy-DOTA-HQ5, 124Iy-DOTA-HQ5, 153Gdy-DOTA-HQ5, 159Gdy-DOTA-HQ5, 177Luy-DOTA-HQ5, 64Cuy-DOTA-CW800, 67Cuy-DOTA-CW800, 67Gay-DOTA-CW800, 68Gay-DOTA-CW800, 70Gay-DOTA-CW800, 72Gay-DOTA-CW800, 89Zry-DOTA-CW800, 90Yy-DOTA-CW800, 95Zry-DOTA-CW800, 111Iny-DOTA-CW800, 114Iny-DOTA-CW800, 123Iy-DOTA-CW800, 124Iy-DOTA-CW800, 153Gdy-DOTA-CW800, 159Gdy-DOTA-CW800, 177Luy-DOTA-CW800, 64Cuy-DOTA-ZW800, 67Cuy-DOTA-ZW800, 67Gay-DOTA-ZW800, 68Gay-DOTA-ZW800, 70Gay-DOTA-ZW800, 72Gay-DOTA-ZW800, 89Zry-DOTA-ZW800, 90Yy-DOTA-ZW800, 95Zry-DOTA-ZW800, 111Iny-DOTA-ZW800, 114Iny-DOTA-ZW800, 123Iy-DOTA-ZW800, 124Iy-DOTA-ZW800, 153Gdy-DOTA-ZW800, 159Gdy-DOTA-ZW800, 177Luy-DOTA-ZW800, 64Cuy-NOTA-HQ4, 67Cuy-NOTA-HQ4, 67Gay-NOTA-HQ4, 68Gay-NOTA-HQ4, 70Gay-NOTA-HQ4, 72Gay-NOTA-HQ4, 89Zry-NOTA-HQ4, 90Yy-NOTA-HQ4, 95Zry-NOTA-HQ4, 111Iny-NOTA-HQ4, 114Iny-NOTA-HQ4, 123Iy-NOTA-HQ4, 124Iy-NOTA-HQ4, 153Gdy-NOTA-HQ4, 159Gdy-NOTA-HQ4, 177Luy-NOTA-HQ4, 64Cuy-NOTA-HQ5, 67Cuy-NOTA-HQ5, 67Gay-NOTA-HQ5, 68Gay-NOTA-HQ5, 70Gay-NOTA-HQ5, 72Gay-NOTA-HQ5, 89Zry-NOTA-HQ5, 90Yy-NOTA-HQ5, 95Zry-NOTA-HQ5, 111Iny-NOTA-HQ5, 114Iny-NOTA-HQ5, 123Iy-NOTA-HQ5, 124Iy-NOTA-HQ5, 153Gdy-NOTA-HQ5, 159Gdy-NOTA-HQ5, 177Luy-NOTA-HQ5, 64Cuy-NOTA-CW800, 67Cuy-NOTA-CW800, 67Gay-NOTA-CW800, 68Gay-NOTA-CW800, 70Gay-NOTA-CW800, 72Gay-NOTA-CW800, 89Zry-NOTA-CW800, 90Yy-NOTA-CW800, 95Zry-NOTA-CW800, 111Iny-NOTA-CW800, 114Iny-NOTA-CW800, 123Iy-NOTA-CW800, 124Iy-NOTA-CW800, 153Gdy-NOTA-CW800, 159Gdy-NOTA-CW800, 177Luy-NOTA-CW800, 64Cuy-NOTA-ZW800, 67Cuy-NOTA-ZW800, 67Gay-NOTA-ZW800, 68Gay-NOTA-ZW800, 70Gay-NOTA-ZW800, 72Gay-NOTA-ZW800, 89Zry-NOTA-ZW800, 90Yy-NOTA-ZW800, 95Zry-NOTA-ZW800, 111Iny-NOTA-ZW800, 114Iny-NOTA-ZW800, 123Iy-NOTA-ZW800, 124Iy-NOTA-ZW800, 153Gdy-NOTA-ZW800, 159Gdy-NOTA-ZW800, 177Luy-NOTA-ZW800, and combinations thereof, wherein y∈[1,2,3,4].
A targeting system drug for intestine cancer selected from 64Cuy-DOTA-HQ4, 67Cuy-DOTA-HQ4, 67Gay-DOTA-HQ4, 68Gay-DOTA-HQ4, 70Gay-DOTA-HQ4, 72Gay-DOTA-HQ4, 89Zry-DOTA-HQ4, 90Yy-DOTA-HQ4, 95Zry-DOTA-HQ4, 111Iny-DOTA-HQ4, 114Iny-DOTA-HQ4, 123Iy-DOTA-HQ4, 124Iy-DOTA-HQ4, 153Gdy-DOTA-HQ4, 159Gdy-DOTA-HQ4, 177Luy-DOTA-HQ4, 64Cuy-DOTA-HQ5, 67Cuy-DOTA-HQ5, 67Gay-DOTA-HQ5, 68Gay-DOTA-HQ5, 70Gay-DOTA-HQ5, 72Gay-DOTA-HQ5, 89Zry-DOTA-HQ5, 90Yy-DOTA-HQ5, 95Zry-DOTA-HQ5, 111Iny-DOTA-HQ5, 114Iny-DOTA-HQ5, 123Iy-DOTA-HQ5, 124Iy-DOTA-HQ5, 153Gdy-DOTA-HQ5, 159Gdy-DOTA-HQ5, 177Luy-DOTA-HQ5, 64Cuy-DOTA-CW800, 67Cuy-DOTA-CW800, 67Gay-DOTA-CW800, 68Gay-DOTA-CW800, 70Gay-DOTA-CW800, 72Gay-DOTA-CW800, 89Zry-DOTA-CW800, 90Yy-DOTA-CW800, 95Zry-DOTA-CW800, 111Iny-DOTA-CW800, 114Iny-DOTA-CW800, 123Iy-DOTA-CW800, 124Iy-DOTA-CW800, 153Gdy-DOTA-CW800, 159Gdy-DOTA-CW800, 177Luy-DOTA-CW800, 64Cuy-DOTA-ZW800, 67Cuy-DOTA-ZW800, 67Gay-DOTA-ZW800, 68Gay-DOTA-ZW800, 70Gay-DOTA-ZW800, 72Gay-DOTA-ZW800, 89Zry-DOTA-ZW800, 90Yy-DOTA-ZW800, 95Zry-DOTA-ZW800, 111Iny-DOTA-ZW800, 114Iny-DOTA-ZW800, 123Iy-DOTA-ZW800, 124Iy-DOTA-ZW800, 153Gdy-DOTA-ZW800, 159Gdy-DOTA-ZW800, 177Luy-DOTA-ZW800, 64Cuy-NOTA-HQ4, 67Cuy-NOTA-HQ4, 67Gay-NOTA-HQ4, 68Gay-NOTA-HQ4, 70Gay-NOTA-HQ4, 72Gay-NOTA-HQ4, 89Zry-NOTA-HQ4, 90Yy-NOTA-HQ4, 95Zry-NOTA-HQ4, 111Iny-NOTA-HQ4, 114Iny-NOTA-HQ4, 123Iy-NOTA-HQ4, 124Iy-NOTA-HQ4, 153Gdy-NOTA-HQ4, 159Gdy-NOTA-HQ4, 177Luy-NOTA-HQ4, 64Cuy-NOTA-HQ5, 67Cuy-NOTA-HQ5, 67Gay-NOTA-HQ5, 68Gay-NOTA-HQ5, 70Gay-NOTA-HQ5, 72Gay-NOTA-HQ5, 89Zry-NOTA-HQ5, 90Yy-NOTA-HQ5, 95Zry-NOTA-HQ5, 111Iny-NOTA-HQ5, 114Iny-NOTA-HQ5, 123Iy-NOTA-HQ5, 124Iy-NOTA-HQ5, 153Gdy-NOTA-HQ5, 159Gdy-NOTA-HQ5, 177Luy-NOTA-HQ5, 64Cuy-NOTA-CW800, 67Cuy-NOTA-CW800, 67Gay-NOTA-CW800, 68Gay-NOTA-CW800, 70Gay-NOTA-CW800, 72Gay-NOTA-CW800, 89Zry-NOTA-CW800, 90Yy-NOTA-CW800, 95Zry-NOTA-CW800, 111Iny-NOTA-CW800, 114Iny-NOTA-CW800, 123Iy-NOTA-CW800, 124Iy-NOTA-CW800, 153Gdy-NOTA-CW800, 159Gdy-NOTA-CW800, 177Luy-NOTA-CW800, 64Cuy-NOTA-ZW800, 67Cuy-NOTA-ZW800, 67Gay-NOTA-ZW800, 68Gay-NOTA-ZW800, 70Gay-NOTA-ZW800, 72Gay-NOTA-ZW800, 89Zry-NOTA-ZW800, 90Yy-NOTA-ZW800, 95Zry-NOTA-ZW800, 111Iny-NOTA-ZW800, 114Iny-NOTA-ZW800, 123Iy-NOTA-ZW800, 124Iy-NOTA-ZW800, 153Gdy-NOTA-ZW800, 159Gdy-NOTA-ZW800, 177Luy-NOTA-ZW800, and combinations thereof, wherein y∈[1,2,3,4].
A targeting system drug for brain cancer selected from 64Cuy-DOTA-HQ4, 67Cuy-DOTA-HQ4, 67Gay-DOTA-HQ4, 68Gay-DOTA-HQ4, 70Gay-DOTA-HQ4, 72Gay-DOTA-HQ4, 89Zry-DOTA-HQ4, 90Yy-DOTA-HQ4, 95Zry-DOTA-HQ4, 111Iny-DOTA-HQ4, 114Iny-DOTA-HQ4, 123Iy-DOTA-HQ4, 124Iy-DOTA-HQ4, 153Gdy-DOTA-HQ4, 159Gdy-DOTA-HQ4, 177Luy-DOTA-HQ4, 64Cuy-DOTA-HQ5, 67Cuy-DOTA-HQ5, 67Gay-DOTA-HQ5, 68Gay-DOTA-HQ5, 70Gay-DOTA-HQ5, 72Gay-DOTA-HQ5, 89Zry-DOTA-HQ5, 90Yy-DOTA-HQ5, 95Zry-DOTA-HQ5, 111Iny-DOTA-HQ5, 114Iny-DOTA-HQ5, 123Iy-DOTA-HQ5, 124Iy-DOTA-HQ5, 153Gdy-DOTA-HQ5, 159Gdy-DOTA-HQ5, 177Luy-DOTA-HQ5, 64Cuy-DOTA-CW800, 67Cuy-DOTA-CW800, 67Gay-DOTA-CW800, 68Gay-DOTA-CW800, 70Gay-DOTA-CW800, 72Gay-DOTA-CW800, 89Zry-DOTA-CW800, 90Yy-DOTA-CW800, 95Zry-DOTA-CW800, 111Iny-DOTA-CW800, 114Iny-DOTA-CW800, 123Iy-DOTA-CW800, 124Iy-DOTA-CW800, 153Gdy-DOTA-CW800, 159Gdy-DOTA-CW800, 177Luy-DOTA-CW800, 64Cuy-DOTA-ZW800, 67Cuy-DOTA-ZW800, 67Gay-DOTA-ZW800, 68Gay-DOTA-ZW800, 70Gay-DOTA-ZW800, 72Gay-DOTA-ZW800, 89Zry-DOTA-ZW800, 90Yy-DOTA-ZW800, 95Zry-DOTA-ZW800, 111Iny-DOTA-ZW800, 114Iny-DOTA-ZW800, 123Iy-DOTA-ZW800, 124Iy-DOTA-ZW800, 153Gdy-DOTA-ZW800, 159Gdy-DOTA-ZW800, 177Luy-DOTA-ZW800, 64Cuy-NOTA-HQ4, 67Cuy-NOTA-HQ4, 67Gay-NOTA-HQ4, 68Gay-NOTA-HQ4, 70Gay-NOTA-HQ4, 72Gay-NOTA-HQ4, 89Zry-NOTA-HQ4, 90Yy-NOTA-HQ4, 95Zry-NOTA-HQ4, 111Iny-NOTA-HQ4, 114Iny-NOTA-HQ4, 123Iy-NOTA-HQ4, 124Iy-NOTA-HQ4, 153Gdy-NOTA-HQ4, 159Gdy-NOTA-HQ4, 177Luy-NOTA-HQ4, 64Cuy-NOTA-HQ5, 67Cuy-NOTA-HQ5, 67Gay-NOTA-HQ5, 68Gay-NOTA-HQ5, 70Gay-NOTA-HQ5, 72Gay-NOTA-HQ5, 89Zry-NOTA-HQ5, 90Yy-NOTA-HQ5, 95Zry-NOTA-HQ5, 111Iny-NOTA-HQ5, 114Iny-NOTA-HQ5, 123Iy-NOTA-HQ5, 124Iy-NOTA-HQ5, 153Gdy-NOTA-HQ5, 159Gdy-NOTA-HQ5, 177Luy-NOTA-HQ5, 64Cuy-NOTA-CW800, 67Cuy-NOTA-CW800, 67Gay-NOTA-CW800, 68Gay-NOTA-CW800, 70Gay-NOTA-CW800, 72Gay-NOTA-CW800, 89Zry-NOTA-CW800, 90Yy-NOTA-CW800, 95Zry-NOTA-CW800, 111Iny-NOTA-CW800, 114Iny-NOTA-CW800, 123Iy-NOTA-CW800, 124Iy-NOTA-CW800, 153Gdy-NOTA-CW800, 159Gdy-NOTA-CW800, 177Luy-NOTA-CW800, 64Cuy-NOTA-ZW800, 67Cuy-NOTA-ZW800, 67Gay-NOTA-ZW800, 68Gay-NOTA-ZW800, 70Gay-NOTA-ZW800, 72Gay-NOTA-ZW800, 89Zry-NOTA-ZW800, 90Yy-NOTA-ZW800, 95Zry-NOTA-ZW800, 111Iny-NOTA-ZW800, 114Iny-NOTA-ZW800, 123Iy-NOTA-ZW800, 124Iy-NOTA-ZW800, 153Gdy-NOTA-ZW800, 159Gdy-NOTA-ZW800, 177Luy-NOTA-ZW800, and combinations thereof, wherein y∈[1,2,3,4].
A targeting system drug for pharynx cancer or for larynx cancer selected from 64Cuy-DOTA-HQ4, 67Cuy-DOTA-HQ4, 67Gay-DOTA-HQ4, 68Gay-DOTA-HQ4, 70Gay-DOTA-HQ4, 72Gay-DOTA-HQ4, 89Zry-DOTA-HQ4, 90Yy-DOTA-HQ4, 95Zry-DOTA-HQ4, 111Iny-DOTA-HQ4, 114Iny-DOTA-HQ4, 123Iy-DOTA-HQ4, 124Iy-DOTA-HQ4, 153Gdy-DOTA-HQ4, 159Gdy-DOTA-HQ4, 177Luy-DOTA-HQ4, 64Cuy-DOTA-HQ5, 67Cuy-DOTA-HQ5, 67Gay-DOTA-HQ5, 68Gay-DOTA-HQ5, 70Gay-DOTA-HQ5, 72Gay-DOTA-HQ5, 89Zry-DOTA-HQ5, 90Yy-DOTA-HQ5, 95Zry-DOTA-HQ5, 111Iny-DOTA-HQ5, 114Iny-DOTA-HQ5, 123Iy-DOTA-HQ5, 124Iy-DOTA-HQ5, 153Gdy-DOTA-HQ5, 159Gdy-DOTA-HQ5, 177Luy-DOTA-HQ5, 64Cuy-DOTA-CW800, 67Cuy-DOTA-CW800, 67Gay-DOTA-CW800, 68Gay-DOTA-CW800, 70Gay-DOTA-CW800, 72Gay-DOTA-CW800, 89Zry-DOTA-CW800, 90Yy-DOTA-CW800, 95Zry-DOTA-CW800, 111Iny-DOTA-CW800, 114Iny-DOTA-CW800, 123Iy-DOTA-CW800, 124Iy-DOTA-CW800, 153Gdy-DOTA-CW800, 159Gdy-DOTA-CW800, 177Luy-DOTA-CW800, 64Cuy-DOTA-ZW800, 67Cuy-DOTA-ZW800, 67Gay-DOTA-ZW800, 68Gay-DOTA-ZW800, 70Gay-DOTA-ZW800, 72Gay-DOTA-ZW800, 89Zry-DOTA-ZW800, 90Yy-DOTA-ZW800, 95Zry-DOTA-ZW800, 111Iny-DOTA-ZW800, 114Iny-DOTA-ZW800, 123Iy-DOTA-ZW800, 124Iy-DOTA-ZW800, 153Gdy-DOTA-ZW800, 159Gdy-DOTA-ZW800, 177Luy-DOTA-ZW800, 64Cuy-NOTA-HQ4, 67Cuy-NOTA-HQ4, 67Gay-NOTA-HQ4, 68Gay-NOTA-HQ4, 70Gay-NOTA-HQ4, 72Gay-NOTA-HQ4, 89Zry-NOTA-HQ4, 90Yy-NOTA-HQ4, 95Zry-NOTA-HQ4, 111Iny-NOTA-HQ4, 114Iny-NOTA-HQ4, 123Iy-NOTA-HQ4, 124Iy-NOTA-HQ4, 153Gdy-NOTA-HQ4, 159Gdy-NOTA-HQ4, 177Luy-NOTA-HQ4, 64Cuy-NOTA-HQ5, 67Cuy-NOTA-HQ5, 67Gay-NOTA-HQ5, 68Gay-NOTA-HQ5, 70Gay-NOTA-HQ5, 72Gay-NOTA-HQ5, 89Zry-NOTA-HQ5, 90Yy-NOTA-HQ5, 95Zry-NOTA-HQ5, 111Iny-NOTA-HQ5, 114Iny-NOTA-HQ5, 123Iy-NOTA-HQ5, 124Iy-NOTA-HQ5, 153Gdy-NOTA-HQ5, 159Gdy-NOTA-HQ5, 177Luy-NOTA-HQ5, 64Cuy-NOTA-CW800, 67Cuy-NOTA-CW800, 67Gay-NOTA-CW800, 68Gay-NOTA-CW800, 70Gay-NOTA-CW800, 72Gay-NOTA-CW800, 89Zry-NOTA-CW800, 90Yy-NOTA-CW800, 95Zry-NOTA-CW800, 111Iny-NOTA-CW800, 114Iny-NOTA-CW800, 123Iy-NOTA-CW800, 124Iy-NOTA-CW800, 153Gdy-NOTA-CW800, 159Gdy-NOTA-CW800, 177Luy-NOTA-CW800, 64Cuy-NOTA-ZW800, 67Cuy-NOTA-ZW800, 67Gay-NOTA-ZW800, 68Gay-NOTA-ZW800, 70Gay-NOTA-ZW800, 72Gay-NOTA-ZW800, 89Zry-NOTA-ZW800, 90Yy-NOTA-ZW800, 95Zry-NOTA-ZW800, 111Iny-NOTA-ZW800, 114Iny-NOTA-ZW800, 123Iy-NOTA-ZW800, 124Iy-NOTA-ZW800, 153Gdy-NOTA-ZW800, 159Gdy-NOTA-ZW800, 177Luy-NOTA-ZW800, and combinations thereof, wherein y∈[1,2,3,4].
(canceled)
Dependencies are inferred from the claim text.