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US 2022/0175968 A1Published application
Non-active lipid nanoparticles with non-viral, capsid free dna
AssigneeGeneration Bio Co.
InventorsMatthew G. Stanton, Matthew Manganiello
Life of this patent
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Abstract
Provided herein are compositions and methods for delivering non-viral, capsid-free DNA vectors (ceDNA) to cytosol of a target cell in subject while reducing or inhibiting an immune response.
Claims190
A method of delivering a capsid free, non-viral vector to the cytosol of a target cell within a subject, the method comprising co-administering to the subject:
- a. a capsid free, non-viral vector encapsulated in a lipid nanoparticle (LNP), wherein the LNP lacks fusogenic activity;
- and
- b. an endosomolytic agent.
A method of delivering a capsid free, non-viral vector to the cytosol of a target cell within a subject, the method comprising co-administering to the subject:
- a. a capsid free, non-viral vector encapsulated in a lipid nanoparticle (LNP), wherein the LNP lacks fusogenic activity;
- and
- b. an endosomolytic agent,
- wherein at least one of the lipid nanoparticle and the endosomolytic agent includes a first targeting ligand that binds to a molecule on the surface of the target cell.
1 more element
A composition comprising:
- a. a capsid free, non-viral vector encapsulated in a lipid nanoparticle (LNP), wherein the LNP lacks fusogenic activity;
- and
- b. an endosomolytic agent.
Dependencies are inferred from the claim text.