Back to results
US 2022/0175959 A1Published application
Microparticles and nanoparticles having sulfate groups on the surface
AssigneePhosphorex, Inc.
InventorBin Wu
Life of this patent
Estimating the term…
Abstract
This invention provides polymer particles which contain negative charges on the surface of the particle. Preferably, the particles comprise PLGA and sulfate polymer. The invention also provides polymer particle produced by the methods of the invention.
Claims18
Particles having negative surface charges, comprising polylactide-co-glycolide (PLGA) and a sulfate polymer, such as a sulfate polysaccharide, e.g., heparan sulfate, carrageenan, fucoidan, and ulvan.
A method for the preparation of microparticles or nanoparticles comprising:
- (1) dissolving PLGA (and optionally an active agent, such as a pharmaceutical ingredient (API), or a poorly water soluble compound) in a first solvent to form a PLGA solution;
- (2) emulsifying the polymer solution in a solution of a second solvent to form an emulsion, wherein the first solvent is not miscible or partially miscible with the second solvent, and wherein the solution of the second solvent comprises a sulfate polymer, said solution of the second solvent optionally further comprising a surfactant and/or an API soluble in the second solvent;
- and, (3) removing the first solvent to form said microparticles or nanoparticles having negative surface charges.
Dependencies are inferred from the claim text.