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US 2022/0175953 A1Published application
Biomimetic anisotropic polymeric particles with naturally derived cell membranes for enhanced drug delivery
AssigneeThe Johns Hopkins University
InventorsJordan J. Green, Randall A. Meyer, Elana Ben-Akiva
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Abstract
The presently disclosed subject matter provides a biomimetic particle platform that can be used to simulate natural cells found throughout the body. The particle comprises a polymeric core of defined shape, size, and mechanical properties and a surface comprising naturally derived cell membranes, such as red blood cells or platelets. Together these features enable a level of biomimicry that can be appropriated for various drug delivery applications and cell engineering applications.
Claims32
-26. (canceled)
A biomimetic particle comprising:
- (i) a three-dimensional microparticle or nanoparticle having an asymmetrical shape defined by a dimension (a) along an x-axis, a dimension (b) along a y-axis, and a dimension (c) along a z-axis, wherein at least one of (a), (b), or (c) is not equal to at least one other dimension (a), (b), or (c);
- and
- (ii) a naturally derived cell membrane.
Dependencies are inferred from the claim text.