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US 2022/0175949 A9Published application
Peptides derived from transient receptor potential cation channel subfamily m member 1 (trpm1), complexes comprising such peptides bound to mhc molecules
OwnerAlex POWLESLAND, Maurits KLEIJNEN +1inventors
InventorsAlex POWLESLAND, Maurits KLEIJNEN, Meidai SUN
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Abstract
The present invention relates to novel peptides derived from Transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.
Claims20
A polypeptide comprising:
- (a) the amino acid sequence of any one of SEQ ID NOS:
- 1-16, or
- (b) the amino acid sequence of any one of SEQ ID NOs:
- 1-16 with the exception of 1, 2 or 3 amino acid substitutions and/or 1, 2 or 3 amino acid insertions, and/or 1, 2 or 3 amino acid deletions,
- wherein the polypeptide is capable of forming a complex with a Major Histocompatibility Complex (MHC) molecule.
2 more elements
Dependencies are inferred from the claim text.