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US 2022/0175942 A1Published application
Evasins for use in therapy and diagnostics
AssigneeOxford University Innovation Limited
InventorShoumo Bhattacharya
Life of this patent
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Abstract
The invention relates to novel Evasin polypeptides with novel chemokine-binding properties and their use in inhibiting chemokines or detecting chemokine expression and inflammation.
Claims18
-28. (canceled)
A composition comprising:
- (I) a polypeptide comprising (a) all or part of an amino acid sequence shown in any one of SEQ ID NOs:
- 1 to 31:
- or (b) all or part of an amino acid sequence characterized by at least 70% homology or amino identity to a sequence of (a) over its entire length;
- or
- (II) a fusion polypeptide comprising a polypeptide according to (I) linked to a second peptide or polypeptide;
- or
- (III) a combination of two or more polypeptides according to (I) or (II).
4 more elements
A method of inhibiting the signalling of one or more chemokines in a subject, the method comprising administering to the subject:
- (I) a polypeptide comprising (a) all or part of an amino acid sequence shown in any one of SEQ ID NOs:
- 1 to 31;
- or (b) all or part of an amino acid sequence characterized by at least 70% homology or amino identity to a sequence of (a) over its entire length, (II) a fusion polypeptide comprising a polypeptide according to (I) linked to a second peptide or polypeptide or (III) a combination of two or more of said polypeptides according to (I) or (II).
A method of treating or preventing in a subject one or more diseases associated with one or more chemokines, the method comprising administering to the subject a polypeptide:
- (I) comprising (a) all or part of an amino acid sequence shown in any one of SEQ ID NOs:
- 1 to 31;
- or (b) all or part of an amino acid sequence characterized by at least 70% homology or amino identity to a sequence of (a) over its entire length, (II) a fusion polypeptide comprising a polypeptide according to (I) linked to a second peptide or polypeptide, or (III) a combination of two or more of said polypeptides according to (I) or (II).
Dependencies are inferred from the claim text.