Methods and compositions using peptides and proteins with c-terminal elements
AssigneeSanford Burnham Prebys Medical Discovery Institute
InventorsErkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
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Abstract
Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
Claims34
A method of enhancing internalization, penetration, or both of a co-composition into or through a cell, tissue, or both, the method comprising:
- exposing the cell, tissue, or both to the composition of claim 98, thereby enhancing internalization, penetration, or both of the co-composition into or through the cell, tissue, or both.
A method of enhancing internalization, penetration, or both of a cargo composition into or through a cell, tissue, or both, the method comprising:
- exposing the cell, tissue, or both to the composition of claim 99, thereby enhancing internalization, penetration, or both of the cargo composition into or through the cell, tissue, or both.
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A composition comprising a CendR element and a co-composition, wherein the CendR element and the co-composition are not covalently coupled or directly non-covalently associated with each other,
- wherein the CendR element comprises the sequence X1X2X3X4, wherein X1 is selected from the group consisting of R, K or H, wherein X4 is selected from the group consisting of R, K, H, or KG, and wherein X2 and X3 can each be, independently, any amino acid.
A composition comprising a CendR element and a cargo composition, wherein the CendR element and the cargo composition are covalently coupled or non-covalently associated with each other, wherein the CendR element comprises the sequence X1X2X3X4, wherein X1 is selected from the group consisting of R, K or H, wherein X4 is selected from the group consisting of R, K, H, or KG, and wherein X2 and X3 can each be, independently, any amino acid.
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Dependencies are inferred from the claim text.