Novel Complex Comprising A Cell Penetrating Peptide, A Cargo And A TLR Peptide Agonist For Treatment Of Glioblastoma
AssigneeAmal Therapeutics SA
InventorsMadiha DEROUAZI, Elodie BELNOUE
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Abstract
The present invention provides a novel complex for use in the prevention and/or treatment of glioma, in particular glioblastoma, the complex comprising a) a cell penetrating peptide, b) at least one antigen or antigenic epitope, and c) at least one TLR peptide agonist, wherein the components a)-c) are covalently linked. In particular, compositions for use in the prevention and/or treatment of glioma, in particular glioblastoma, such as a pharmaceutical compositions and vaccines are provided.
Claims24
A method for treating glioma or initiating, enhancing or prolonging an anti-tumor-response in a subject in need thereof, the method comprising administering to the subject a complex comprising:
- a) a cell penetrating peptide;
- b) at least one antigen or antigenic epitope;
- and
- c) at least one TLR peptide agonist, wherein the TLR peptide agonist is a TLR2 or TLR4 peptide agonist,
- wherein the components a)-c) are covalently linked.
Dependencies are inferred from the claim text.