Recombinant proteins with cd40 activating properties
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite Paris Est Creteil Val De Marne, Baylor Research Institute, Assistance Publique-HôPitaux De Paris (Aphp)
InventorsYves LEVY, Valentina CEGLIA, Sandra ZURAWSKI, Gerard ZURAWSKI
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Abstract
The disclosure relates to the field of CD40 activating proteins. More specifically, it is disclosed herein recombinant proteins with CD40 agonist antibodies or their antigen-binding fragments fused or linked to CD40 ligand. Also disclosed is the advantageous use of such CD40 activating proteins, in particular for inducing immune responses directed to delivered antigens such as viral or cancer antigens.
Claims20
A CD40 activating protein comprising at least the following protein domains:
- (i) a CD40 agonist antibody or an antigen-binding fragment thereof (αCD40);
- and,
- (ii) the CD40 binding-domain of CD40L (CD40L).
Dependencies are inferred from the claim text.