Compositions and methods for modulation of antibody activity
AssigneeInstitute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
InventorsJohn Karanicolas, Jittasak Khowsathit, Daniel Pushparaju Yeggoni
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Abstract
Compositions and methods for modulating antibody activity are disclosed.
Claims27
An allosteric antibody comprising at least two amino acid substitutions within an antigen-binding antibody, wherein said amino acid substitutions form a contiguous cavity within the allosteric antibody which can be bound by an effector molecule, wherein the allosteric antibody has reduced binding affinity for antigen, and wherein the binding affinity of the allosteric antibody for antigen is increased or restored upon binding with an effector molecule.
Dependencies are inferred from the claim text.