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US 2022/0175904 A1Published application
Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsGerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
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Abstract
The invention relates to the compositions of synthetic oligo-γ-(1→6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for making and use same.
Claims16
1-59. (canceled)
A method for stimulating an immune response in a subject comprising
- administering to a subject in need thereof the oligosaccharide-carrier conjugate in an amount effective to stimulate an immune response in the subject,
- wherein the oligosaccharide-carrier conjugated comprises an oligosaccharide conjugated to a protein or peptide carrier, through a linker, wherein the oligosaccharide is a β-1,6-linked glucosamine that is 0-40% acetylated and 4-20 monomers in length.
Dependencies are inferred from the claim text.