Methods and pharmaceutical compositions for inducing immune tolerance by mucosal vaccination with fc-coupled antigens
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), Universite Paris Descartes, Universite Pierre Et Marie Curie (Paris 6), Universite Paris Diderot—Paris 7
InventorsRoberto MALLONE, Slobodan CULINA, Nimesh GUPTA, Sebastien LACROIX-DESMAZES
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.
Claims14
A method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.
Dependencies are inferred from the claim text.