Combinations of tannase and probiotic formulations and methods of use for improving tannin metabolism

Abstract

In one aspect, the disclosure relates to pharmaceutical and nutraceutical formulations that overcome inflammatory bowel disease and other disorders or diseases associated with a deficiency in microflora catabolize hydrolyzable tannins Disclosed are methods of using an acid-tolerant tannase that allow the stomach to serve as a “bioreactor” followed by the small intestine for optimal activity, while probiotic strains that specifically target tannins are simultaneously consumed, aiding in the hydrolysis and metabolism. Through colonization, these bacteria can establish and proliferate, and adaption leads to a decrease of the “bad” bacteria while the targeted bacteria proliferate. The formulations and methods provided herein present a short-term (tannase) and long-term (pre- and pro-biotic) solution to poor tannin metabolism. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Dependencies are inferred from the claim text.