Methods of treating cancer by targeting tumor-associated macrophages
AssigneesEndocyte, Inc., Purdue Research Foundation
InventorsYingjuan J. LU, Leroy W. WHEELER, II, Philip Stewart LOW, Christopher Paul LEAMON
Life of this patent
Estimating the term…
Abstract
Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.
Claims27
A method for treating a cancer comprising the steps of identifying the presence of tumor-associated macrophages in the cancer in a host animal, and administering to the host animal a therapeutically effective amount of one or more compounds comprising a folate receptor binding compound attached to a drug via a linker.
A method for treating a cancer in a host animal, the method comprising the step of administering to the host animal a therapeutically effective amount of one or more compounds comprising a folate receptor binding compound attached to a drug via a linker to inhibit or deplete tumor-associated macrophages in the host animal.
A method for targeting tumor-associated macrophages in a host animal, the method comprising the step of administering to the host animal a therapeutically or diagnostically effective amount of one or more compounds comprising a folate receptor binding compound attached to a drug via a linker to target the tumor-associated macrophages.
-8. (canceled)
(canceled)
(canceled)
-16. (canceled)
-25. (canceled)
-41. (canceled)
Dependencies are inferred from the claim text.