Polymeric nanoparticles and a process of preparation thereof
AssigneeHillstream BioPharma, Inc.
InventorHarpal SINGH
Life of this patent
Estimating the term…
Abstract
The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from 30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also disclosed.
Claims21
1-66. (canceled)
Biodegradable polymeric nanoparticles comprising a poly(lactic acid-polyethylene glycol-polypropylene glycol-polyethylene glycol (PLA-PEG-PPG-PEG) tetra block copolymer or a PLA-PEG-PPG-PEG-PLA penta block copolymer.
A method for treating cancer in a subject in need thereof comprising administering the biodegradable polymeric nanoparticles of claim 6 to the subject, wherein the therapeutic agent is selected from the group consisting of an anti-cancer peptide, DNA, oligonucleotide, siRNA and a chemotherapeutic.
Dependencies are inferred from the claim text.