Synthetic neuromodulatory peptides
AssigneeLactocore, Inc.
InventorsAnton MALYSHEV, Igor DORONIN, Gennady BABKIN, Askar KUCHUMOV
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Abstract
A pharmaceutical composition comprising a synthetic neuromodulatory peptide is described. The invention discloses neuromodulatory peptides as defined in the claims and methods of using such molecules for therapeutic application. The neuromodulatory peptides included in the composition have been found to be effective in treatment of depression and other mood disorders, including anxiety.
Claims98
A composition comprising a synthetic neuromodulatory peptide, the neuromodulatory peptide being defined by the general formula I:
- R1R2R3R4 (I)
- wherein:
- R1 is selected from the amino acids W, F, and D;
- R2 is a hydrophilic amino acid;
- R3 is a hydrophilic amino acid;
- and
- R4 is selected from the amino acids V and E.
A composition comprising a neuromodulatory peptide, the neuromodulatory peptide being defined by the general formula Ia:
- R1R2R3R4 (Ia)
- wherein:
- R1 is selected from the amino acids W, F, and D;
- R2 is selected from the amino acids D, Q, and K;
- R3 is a polar and neutral of charge hydrophilic amino acid;
- and
- R4 is selected from the amino acids V and E.
Dependencies are inferred from the claim text.