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US 2022/0175872 A1Published application
Thermogenic compositions and methods
AssigneeOhio State Innovation Foundation
InventorsOuliana Ziouzenkova, Jonathan R. Parquette
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AssigneeOhio State Innovation Foundation
InventorsOuliana Ziouzenkova, Jonathan R. Parquette
Estimating the term…
Thermogenic molecules and methods of using these molecules for treating or preventing a condition in a subject selected from the group consisting of visceral fat accumulation (e.g., Crohn's disease associated with visceral fat accumulation), obesity, diabetes, pre-diabetes, hypothermia, and chronic inflammation are disclosed. Also disclosed is a method for promoting glucose uptake in peripheral tissues (e.g., adipocytes and muscles) of a subject, enhancing nerve innervation in a subject, activating PI3 kinase in cell, and inducing leptin secretion by an adipocyte. Also disclosed are inhibitors of thermogenic molecules and methods of using these inhibitors to decrease thermogenesis of adipocytes in a subject. Also disclosed are self-assembled, biocompatible nanostructure non-covalently associated with a therapeutic or diagnostic peptide or peptidomimetic.
1-5. (canceled)
A method for treating or preventing a condition in a subject selected from the group consisting of visceral fat accumulation, obesity, diabetes, pre-diabetes, hypothermia, and chronic inflammation, comprising administering to the subject an effective amount of the composition of claim 15.
A method for promoting glucose uptake in peripheral tissues of a subject, comprising administering to the subject an effective amount of the composition of claim 15.
The method of claim 0, further comprising administering to the subject a therapeutically effective amount of an epidermal growth factor receptor (EGFR) inhibitor, an ErbB receptor inhibitor, a MAPK inhibitor, or a combination thereof.
The method of claim 0, wherein the subject is resistant to insulin.
A method for enhancing nerve innervation in a subject, comprising administering to the subject an effective amount of the composition of claim 15.
(canceled)
A pharmaceutical composition comprising a self-assembled, biocompatible nanostructure non-covalently associated with a thermogenesis-inducing molecule, wherein the self-assembled, biocompatible nanostructure is formed from a hydrophobic dipeptide or tetrapeptide optionally having a N-terminal protection, wherein the hydrophobic dipeptide or tetrapeptide is coniugated to a hydrophobic aromatic moiety.
16-19. (canceled)
25-28. (canceled)
(canceled)
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Dependencies are inferred from the claim text.