Compositions, methods for regulating uterine, placental growth
AssigneeThe Regents of the University of California
InventorsElaine Y. Hsiao, Geoffrey N. Pronovost
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Abstract
Disclosed herein are methods for promoting fetal growth, placental development, and angiogenesis, comprising administering to a female subject or to a maternal subject gestating an unborn baby (e.g., fetus) a composition of the present disclosure. Also disclosed are methods of inhibiting development of a disease or disorder, such as preeclampsia or fetal growth reduction (FGR), in a subject, comprising administering to a female subject or to a maternal subject gestating an unborn baby (e.g., fetus) a composition of the present disclosure.
Claims24
A method comprising administering to a subject a composition comprising:
- a compound selected from primary bile acids, secondary bile acids, daidzein, genistein, osteopontin, osteoglycin, pleiotrophin, tyrosine, histidine, peptides, benzoate, tryptophan, 2-aminophenol sulfate, catechol sulfate, 4-hydroxyphenylacetate sulfate, N,N,N-trimethyl-5-aminovalerate, phenol sulfate, equol sulfate, hippurate, p-cresol sulfate, imidazolepropionate, indolepropionate, equol glucuronide, valerylglycine, phenol glucuronide, salicylate, S-carboxymethyl-L-cysteine, and trimethylamine N-oxide, and metabolites and derivatives thereof, or a combination thereof;
- and/or
- one or more bacterial species found in a maternal microbiome, selected from phylum Firmicutes, phylum Bacteroidetes, phylum Proteobacteria, or a combination thereof.
4-5. (canceled)
7-8. (canceled)
10-11. (canceled)
(canceled)
Dependencies are inferred from the claim text.