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US 2022/0175848 A1Published application
Methods and compositions for cell therapy
AssigneesThe Broad Institute, Inc., The Brigham and Women's Hospital, Inc.
InventorsAmit CHOUDHARY, Sreekanth VEDAGOPURAM, Donghyun LIM
Life of this patent
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Abstract
An engineered cell is provided that may include one or more polynucleotides inserted into a sequence of a secretory protein of the cell, which may be a β-cell.
Claims42
An engineered cell comprising one or more polynucleotides encoding:
- a. one or more secreted proteins, or a functional fragment thereof, wherein the one or more secreted proteins or functional fragments thereof are inserted in one or more endogenous genes of the cell, the one or more endogenous genes encoding a secretory protein or peptide;
- and
- b. an optional co-expressed protein that enhances the expression, stability or biological activity of the secreted protein.
Dependencies are inferred from the claim text.