Multicistronic mirna delivery for cardiac reprogramming
AssigneeDuke University
InventorsConrad P. Hodgkinson, Victor J. Dzau
Life of this patent
Estimating the term…
Abstract
The invention provides a method of promoting reprogramming of a cardiac fibroblast into a cardiomyocyte by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences using a multicistronic expression system for reprogramming of fibroblasts into functional mature cardiomyocytes.
Claims15
A method of promoting reprogramming of a cardiac fibroblast into a cardiomyocytes by contacting the cardiac fibroblast with an isolated polynucleotide molecule comprising at least two functional miRNA sequences selected from the group consisting of miR-1, miR-133, miR-208, and miR-499.
An isolated polynucleotide molecule comprising at least two functional miRNA sequences selected from the group consisting of miR-1, miR-133, miR-208, and miR-499.
Dependencies are inferred from the claim text.