Methods of treating optic nerve diseases using neural progenitor cell growth factors
AssigneesUniversity of Maryland, Baltimore, Regenerative Research Foundation
InventorsSteven Lance BERNSTEIN, Candace L. KERR, Sally TEMPLE STERN
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Abstract
Optic nerve lamina region neural progenitor cells (ONLR-NPCs) are provided. Such cells secrete growth factors and survival factors that can be used in the treatment of optic nerve diseases, such as glaucoma. Also provided are methods of treating or preventing optic nerve diseases, such as glaucoma, using one or more factors secreted by ONLR-NPCs, combinations of factors secreted by ONLR-NPCs, or culture media conditioned by ONLR-NPCs.
Claims17
A method of treating or preventing an optic nerve disease in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising one or more of:
- (i) a population of optic nerve lamina region-neural progenitor cells (ONLR-NPCs),
- (ii) ONLR-NPC conditioned media,
- (iii) an ONLR-NPC lysate,
- (iv) an ONLR-NPC extract, and
- (v) one or more factors secreted by ONLR-NPCs,
- thereby treating or preventing an optic nerve disease in the subject.
Dependencies are inferred from the claim text.