Loading patent…
OwnerDarwin J. PROCKOP, Ashok K. SHETTY +4inventors
InventorsDarwin J. PROCKOP, Ashok K. SHETTY, Qianfa LONG, Dinesh UPADHYA, Bharathi HATTIANGADY, Dong-ki KIM
Estimating the term…
Disclosed are medicaments and methods for inhibiting brain inflammation and the cognitive memory loss attendant brain disease and damage in an animal. Status epilepticus, stroke and Alzheimer's disease are particular pathologies that are treated employing pharmaceutically acceptable preparations of the A1 exosomes. The preparations comprise an enriched population of A1 exosomes, such as exosomes derived from culture medium from mesenchymal stem cells. Medicaments and methods for inhibiting pattern recognition and/or memory impairment attendant a brain injury event or degenerative brain disease are also disclosed, comprising administering a pharmaceutically acceptable preparation of exosomes, particularly A1 exosomes, that are CD9− and that prevent the elevation of pro-inflammatory cytokines attendant a brain injury or disease.
A medicament for inhibiting brain inflammation in an animal subsequent a brain injury comprising a preparation enriched for A1 exosomes, wherein said A1 exosomes have a mean size of about 85 nm to about 250 nm, are CD9−, and prevent an increase IL-6, IFNγ and I1-1β gene expression levels in an animal subsequent a brain injury.
A medicament for preserving memory recognition function in an animal subsequent to a brain function impairing disease, comprising a preparation enriched for A1 exosomes, wherein said A1 exosomes have a mean size of about 85 nm to about 250 nm, are CD9−, and prevents an increase IL-6, IFNγ and I1-1β gene expression levels in an animal subsequent a brain injury.
An exosome preparation comprising an enriched population of A1 exosomes derived from mesenchymal stem cells, said A1 exosomes having the following characteristics:
Dependencies are inferred from the claim text.