The Treatment of Protein Aggregation Diseases
OwnerChristopher Stanleyinventor
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Abstract
Compositions, methods and systems for the treatment of a protein aggregation disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Dementia with Lewy Bodies (DLB), Huntington's disease (HD), Amylotrophic lateral sclerosis (ALS, which results from degeneration of the upper and lower motor neurones and affects the voluntary muscle system), Progressive Supranuclear Palsy (PSP), Type 2 Diabetes and Multiple systems atrophy (MSA).
Claims17
A red blood cell preparation derived from one or more of the following:
- i) a donor or donors;
- ii) the subject's red blood cells or the donor or donor's red blood cells that have been treated ex vivo to reduce the content of protein oligomers and/or aggregates;
- iii) stem cells or other mononuclear cells;
- and
- iv) from a xenotransfusion source,
- wherein the level of oligomers or aggregates of proteins in the red blood cell preparation has been measured and shown to be at a reduced level.
(canceled)
A method of treating a protein aggregation disease in a subject comprising administering red blood cells derived from one or more of the following:
- i) a donor or donors
- ii) the subject's red blood cells or the donor or donor's red blood cells that have been treated ex vivo to reduce the content of protein oligomers and/or aggregates
- iii) derived from stem cells or other mononuclear cells
- iv) from a xenotransfusion source
- wherein the level of protein oligomers or aggregates in the administered red blood cells has been measured and shown to be at a reduced level.
A method of treating a protein aggregation disease comprising removing aggregated proteins from the surface of red blood cells.
A method for removing aggregated proteins from the surface of a red blood cell comprising contacting a subject's red blood cells with means to remove protein aggregates from the surface of a cell.
17-20. (canceled)
Dependencies are inferred from the claim text.