Targeted delivery of immune-modulating vhh and vhh-fusion protein
AssigneesChildren's Medical Center Corporation, Massachusetts Institute of Technology
InventorsYushu J. Xie, Hidde L. Ploegh
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Abstract
Provided herein are engineered cells that comprising a chimeric antigen receptor comprising an extracellular target-binding moiety and an intracellular signaling domain; and secrets a heavy-chain antibody (VHH) or a VHH fusion protein. Methods of using the engineered cell to treat a disease (e.g., cancer or autoimmune disease) are also provided.
Claims47
An engineered cell comprising:
- (i) a nucleotide sequence encoding a chimeric antigen receptor (CAR) comprising an extracellular target-binding moiety and an intracellular signaling domain;
- and
- (ii) a nucleotide sequence encoding a heavy-chain antibody (VHH) or a VHH fusion protein thereof.
An engineered cell comprising a chimeric antigen receptor (CAR) comprising an extracellular target-binding moiety and an intracellular signaling domain, wherein the engineered cell secrets a VHH or a VHH fusion protein.
Dependencies are inferred from the claim text.