Antimicrobial Compositions
AssigneeMatoke Holdings Limited
InventorsStewart Green, Mark Broughton, Wendy Richings-Barrow, Ian Harding
Life of this patent
Estimating the term…
Abstract
Liquid compositions are described which have enzyme that is able to convert a substrate to release hydrogen peroxide; substrate for the enzyme; and polymer. The substrate is less than 10% by weight of the composition and the composition does not comprise sufficient free water to allow the enzyme to convert the substrate, or has a water activity of 0.7 or less.
Claims54
A composition comprising:
- enzyme that is able to convert a substrate to release hydrogen peroxide;
- substrate for the enzyme, the substrate being less than 10% by weight of the composition;
- and
- polymer,
- wherein the composition does not comprise sufficient free water to allow the enzyme to convert the substrate or has a water activity of 0.7 or less
- wherein the composition is a liquid.
A composition according to any preceding claim, wherein the solute is 50% or less, by weight, of the composition, preferably 45% or less by weight of the composition.
A composition according to any preceding claim, which does not comprise honey.
A composition according to any preceding claim, which comprises substantially no oil or lipophilic phase.
A composition according to any preceding claim, comprising non-aqueous solvent.
A composition according to any preceding claim, comprising antioxidant.
A composition according to any preceding claim, wherein the antioxidant is ascorbic acid, tocopherol or ascorbyl palmitate, preferably ascorbic acid.
A composition according to any preceding claim, which comprises substantially no hydrogen peroxide.
A composition according to any preceding claim, wherein hydrogen peroxide is present at a concentration of 6 ppm or less.
A composition according to any preceding claim, which is formulated such that at 24 hours, following a 1:1 dilution (by weight) with water, the level of hydrogen peroxide production increases by a factor of at least 200.
A composition according to any preceding claim, wherein the polymer is polyethylene glycol.
A composition according to any preceding claim, comprising a buffer.
A composition according to any preceding claim, which is at a pH of 5 to 7.5.
A composition according to any preceding claim, wherein the enzyme is glucose oxidase and the substrate for the enzyme is D-glucose.
A composition according to any preceding claim which is sterile.
A composition according to any preceding claim, comprising substantially no zinc oxide, catalase, and/or peroxidase.
A composition according to any preceding claim, wherein the enzyme is a purified enzyme, preferably wherein the enzyme has a mass purity at least 95%, preferably at least 98%.
A composition according to any preceding claim, wherein the substrate is a purified substrate, preferably wherein the substrate has a mass purity of at least 95%, preferably at least 98%.
A composition according to any preceding claim, wherein the enzyme is 0.001% to 0.5%, by weight, of the composition or 0.0025% to 0.2%, by weight, of the composition.
A composition according to any preceding claim, which has a viscosity of 10000 to 20000 mPas at 20° C. and 1 atm, optionally 12000 to 15000 mPas at 20° C. and 1 atm.
A composition according to any preceding claim, with a water activity of 0.6 or less.
A wound dressing which comprises a dressing material for dressing a wound, and a composition according to any preceding claim.
A method of preparing a composition, the method comprising, combining:
- an enzyme that is able to convert a substrate to release hydrogen peroxide;
- a substrate for the enzyme;
- and polymer, wherein the composition is formulated to have a water activity of 0.7 or less, or such that it does not include sufficient free water to allow the enzyme to convert the substrate, wherein the composition is formulated such that it is a liquid, and wherein substrate is added such that it is less than 10% by weight of the composition.
Dependencies are inferred from the claim text.