Aim2 inhibitors and uses thereof
AssigneeUniversity of Massachusetts
InventorsKeitaro Fukuda, John E. Harris, Anastasia Khvorova, Kate Fitzgerald
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Abstract
Described herein are AIM2 inhibitors (e.g., inhibitory nucleic acids), vectors, cells (e.g., dendritic cells), and compositions comprising same, and methods of using same in the treatment of cancer (e.g., melanoma).
Claims22
A double stranded RNA molecule that is between 15 and 35 bases in length, comprising a sense strand and an antisense strand, wherein the antisense strand comprises a region of complementarity that is substantially complementary to a nucleic acid sequence comprising nucleotides 362-380 of SEQ ID NO:46, nucleotides 662-681 of SEQ ID NO:48, nucleotides 714-732 of SEQ ID NO:46, nucleotides 1034-1051 of SEQ ID NO:48, or nucleotides 941-960 of SEQ ID NO:
- 48, optionally wherein the RNA molecule is modified.
(canceled)
-20. (canceled)
-35. (canceled)
Dependencies are inferred from the claim text.