US 2022/0175812 A1 · POLYMER NANOPARTICLE AND DNA NANOSTRUCTURE COMPOSITIONS AND METHODS FOR NON-VIRAL DELIVERY

Abstract

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

Claims20

Dependent claims

A DNA nanostructure delivery composition comprising:

i) a single stranded DNA scaffold and ii) one or more oligonucleotides that bind through complementary base pairing with a segment of the DNA scaffold, wherein the one or more oligonucleotides cause the DNA scaffold to fold, and wherein the composition comprises more than one payload for delivery or a nucleic acid construct payload of 3 kB or more.

Dependencies are inferred from the claim text.

Facts

Application

17/542,055Filed 3 Dec 2021

Priority

3 Dec 2020

Published

9 Jun 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 47/6455
Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT:…
A61K 47/60
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes: the organic…
A61K 47/6929
The form being a solid microparticle having no hollow or gas-filled cores: the form being a nanoparticle, e.g. an immuno-nanoparticle

Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery

Life of this patent

Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery

Life of this patent

Abstract

Claims20