Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

At least one compound chosen from glycomimetic E-selectin antagonists having the following Formulae:

• and pharmaceutically acceptable salts thereof, wherein
• R1 is chosen from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-8 haloalkyl, C2-8 haloalkenyl, C2-8 haloalkynyl,
• groups, wherein n is chosen from integers ranging from 0 to 2, R7 is chosen from H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C4-16 cycloalkylalkyl, and —C(═O)R8 groups, and each R8 is independently chosen from H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C4-16 cycloalkylalkyl, C6-18 aryl, and C1-13 heteroaryl groups;
• R3 is chosen from —OH, —OY1, halo, —NH2, —NHY1, —NY1Y2, —OC(═O)Y1, —NHC(═O)Y1, and —NHC(═O)NHY1 groups, wherein Y1 and Y2, which may be the same or different, are independently chosen from C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C4-16 cycloalkylalkyl, C2-12 heterocyclyl, C6-18 aryl, and C1-13 heteroaryl groups, wherein Y1 and Y2 may join together along with the nitrogen atom to which they are attached to form a ring;
• and
• M is chosen from linker groups.