Combination of minocycline and benzoyl peroxide and method of use thereof
AssigneeSol-Gel Technologies Ltd.
InventorsMoshe ARKIN, Karine NEIMANN, Danil FINKEL-MOISEEV
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Abstract
This invention is directed to a regimen administration of combination of minocycline and benzoyl peroxide and uses thereof for treating a skin disorder such as acne or rosacea.
Claims24
A dual chamber dispenser, having a first chamber charged with a first composition comprising from about 2% w/w to about 10% w/w benzoyl peroxide, and a second chamber charged with a second composition comprising from about 0.5% w/w to about 10% w/w of minocycline or a pharmaceutically acceptable salt thereof, wherein the two compositions are mixed before applying on the skin of a patient in need thereof, thus administering a combination product.
A regimen of administration comprising a once daily or twice daily administration of a therapeutically effective dose of a first composition comprising from about 2% w/w to about 10% w/w benzoyl peroxide, and a second composition comprising from about 0.5% w/w to about 10% w/w of minocycline or a pharmaceutically acceptable salt thereof, wherein the two compositions are concomitantly administered from a dual chamber dispenser or from two separate dispensers and mixed before applying on the skin of a patient in need thereof for up to 2 weeks, up to 1 month, preferably up to 2 months and more preferably up to 3 months.
A method of treating, preventing, or inhibiting acne or rosacea comprising administering to a subject in need thereof between 2% w/w to about 10% w/w benzoyl peroxide and from about 0.25% w/w to about 5% minocycline or a pharmaceutically acceptable salt thereof, wherein the effect of the combination is superior than each of its individual components when administered alone.
A method of treating, preventing, or inhibiting acne or rosacea comprising administering to a subject in need thereof between 2% w/w to about 10% w/w benzoyl peroxide and from about 0.25% w/w to about 5% minocycline or a pharmaceutically acceptable salt thereof, wherein the benzoyl peroxide and the minocycline are co-administered by administration of a single combination composition, or by separate administration of (i) a first composition comprising benzoyl peroxide followed by administration of a second composition comprising minocycline or a pharmaceutically acceptable salt thereof;
- or (ii) a second composition comprising minocycline or a pharmaceutically acceptable salt thereof followed by administration of a first composition comprising benzoyl peroxide.
A kit comprising a first composition comprising from about 2% w/w to about 10% w/w benzoyl peroxide, and a second composition comprising from about 0.5% w/w to about 10% w/w of minocycline or a pharmaceutically acceptable salt thereof, wherein the two compositions are mixed before applying on the skin of a patient in need thereof, thus administering a combination product;
- or administering the first and second composition sequentially.
Dependencies are inferred from the claim text.