Compositions comprising oxygenated cholesterol sulfate and at least one of polyalkylene glycol, carboxymethyl cellulose and polyoxylglyceride
AssigneeDurect Corporation
InventorsAndrew R. Miksztal, WeiQi Lin, Mee Jean Kim, Hongwei Wu, Min L. Lee, Wendy Chao
Life of this patent
Estimating the term…
Abstract
Compositions comprising oxygenated cholesterol sulfates (OCS) are provided. The OCS is, for example, 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or 5-cholesten, 3, 25-diol, disulfate (25HCDS). The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure due to acetaminophen), high cholesterol/high lipids, and various inflammatory diseases and conditions.
Claims26
A composition comprising:
- particles in a vehicle;
- the particles comprising one or more oxygenated cholesterol sulfates (OCS), the particles having a median particle size, as measured by laser diffraction, ranging from 0.1 μm to 500 μm;
- and
- the vehicle comprising at least one polyoxylglyceride,
- wherein the composition is contained within a capsule.
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A method of treating, in a subject in need thereof, at least one of:
- hyperlipidemia or a disease or condition caused by hyperlipidemia;
- dysfunction or failure of at least one organ;
- a lipid metabolism disorder;
- metabolic disorder;
- atherosclerosis;
- injury caused by ischemia;
- unwanted cell death;
- sepsis;
- acute radiation syndrome;
- a liver disorder;
- a lipid accumulation disorder;
- a skin lesion;
- and an inflammatory skin disease;
- the method comprising
- administering to the subject a therapeutically effective amount of a composition comprising:
- particles in a vehicle;
- the particles comprising one or more oxygenated cholesterol sulfates (OCS), the particles having a median particle size, as measured by laser diffraction, ranging from 0.1 μm to 500 μm;
- and
- the vehicle comprising at least one polyoxylglyceride,
- wherein the composition is contained within a capsule.
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Dependencies are inferred from the claim text.