The use of an mglur5 antagonist for treating opioid analgesic tolerance
AssigneeNovartis AG
InventorsRichard Carl Elciario DOLMETSCH, Fabrizio GASPARINI, Baltazar GOMEZ-MANCILLA
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Abstract
The invention relates to the use of a mGluR5 antagonist for the treatment of opioid analgesic tolerance associated with chronic opioid use in chronic pain.
Claims23
-17. (canceled)
A method for treating opioid analgesic tolerance associated with chronic opioid use in chronic pain, in a subject in need thereof, comprising administering to said subject an effective amount of a mGluR5 antagonist.
A combination comprising a mGluR5 antagonist and an opioid.
A method for treating opioid analgesic tolerance associated with chronic opioid use in chronic pain, the treatment reversing opioid analgesic tolerance, in a subject in need thereof, comprising administering to said subject a pharmaceutical composition comprising an effective amount of a mGluR5 antagonist and at least one pharmaceutically acceptable excipient.
A method for treating opioid analgesic tolerance associated with chronic opioid use in chronic pain, in a subject in need thereof, comprising administering to said subject a pharmaceutical combination comprising an effective amount of a mGluR5 antagonist and at least one further pharmaceutical active ingredient.
Dependencies are inferred from the claim text.