Pharmaceutical combinations for treating cancer

1) A pharmaceutical combination comprising:

• (a) a PPAR agonist;
• (b) a compound of the formula I or II
• or pharmaceutically acceptable salts thereof, wherein
• Z is N or CH;
• W is NR2;
• X1 is O, NR4 (where R4 is hydrogen or alkyl), S, or CR5R6 (where R5 and R6 are independently hydrogen or alkyl) or C═O;
• X2 is O or NR7;
• Ar1 is aryl or heteroaryl;
• R2 is hydrogen, alkyl, acyl, alkoxycarbonyl, aryloxycarbonyl, heteroalkylcarbonyl, heteroalkyloxycarbonyl or —R21—R22 where R21 is alkylene or —C(═O)— and R22 is alkyl or alkoxy;
• R1 is hydrogen, alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, cyanoalkyl, heterocyclyl, heterocyclylalkyl, R12—SO2-heterocycloamino (where R12 is haloalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl), —Y1—C(O)—Y2—R11 (where Y1 and Y2 are independently either absent or an alkylene group and R11 is hydrogen, alkyl, haloalkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), (heterocyclyl)(cycloalkyl)alkyl or (heterocyclyl)(heteroaryl)alkyl;
• R3 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, alkylene-C(O)—R31 (where R31 is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylamino or NR32—Y3—R33 (where Y3 is —C(O), —C(O)O—, —C(O)NR34, S(O)2 or S(O)2NR35;
• R32, R34 and R35 are independently hydrogen or alkyl;
• and R33 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally substituted phenyl) or acyl;
• R7 is hydrogen or alkyl;
• and
• R8 and R9 are independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, alkylsulfonyl, arylsulfonyl, —C(O)—R81 (where R81 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, alkoxy, aryloxy, amino, mono- or di-alkylamino, arylamino or aryl(alkyl)amino) or R8 and R9 together form ═CR82R83 (where R82 and R83 are independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl or optionally substituted phenyl);
• and optionally
• (c) one or more pharmaceutically acceptable diluents, excipients or carriers.