US 2022/0175782 A1 · KRAS G12C INHIBITORS AND METHODS OF USING THE SAME

Kras g12c inhibitors and methods of using the same

AssigneeAmgen Inc.

InventorsJohn Gordon ALLEN, Brian Alan LANMAN, Jian CHEN, Anthony B. REED, Victor J. CEE, Longbin LIU, Patricia LOPEZ, Ryan Paul WURZ, Thomas T. NGUYEN, Shon BOOKER, Jennifer Rebecca ALLEN, Margaret CHU-MOYER, Albert AMEGADZIE, Ning CHEN, Clifford GOODMAN, Jonathan D. LOW, Vu Van MA, Ana Elena MINATTI, Nobuko NISHIMURA, Alexander J. PICKRELL, Hui-Ling WANG, Youngsook SHIN, Aaron C. SIEGMUND, Kevin C. YANG, Nuria A. TAMAYO, Mary WALTON, Qiufen XUE

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Abstract

Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Claims21

Dependent claims

A compound having a structure selected from the formula

or a stereoisomer thereof, an atropisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer thereof, or a pharmaceutically acceptable salt of the atropisomer thereof.

Dependencies are inferred from the claim text.

Facts

Application

17/579,359Filed 19 Jan 2022

Priority

12 Jun 2018

Published

9 Jun 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61K 31/551
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having two nitrogen atoms, e.g. dilazep
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Family

Application62/684,117Us provisional application · filed 12 Jun 2018

Application16/438,349Division · filed 11 Jun 2019

Application17/579,359Division

US 11,285,156 B2Related patent

US 12,083,121 B2Related patent

US 2019/0374542 A1Published application

US 2022/0175782 A1This patent

From the US filing history. Foreign family members aren’t listed.