Cd40l compositions and methods for tunable regulation

10-12. (canceled)

An effector module, said effector module comprising a drug responsive element (DRD) operably linked to a payload, wherein said DRD comprises, in whole or in part, an ER, an ecDHFR, a FKBP, a PDE5, or an hDHFR protein comprising one or more mutations and wherein said payload comprises in whole or in part a human CD40L comprising one or more mutations.

(canceled)

-44. (canceled)