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US 2022/0175765 A1Published application
Ror-gamma modulators
AssigneeEscalier Biosciences B.V.
InventorsRaju MOHAN, John NUSS, Jason HARRIS
Life of this patent
Estimating the term…
Abstract
Described herein are retinoic acid related-related orphan nuclear receptor (ROR) modulators and methods of utilizing RORγ modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
Claims69
A compound having the structure of Formula (I):
- wherein:
- is phenyl, or a 5-membered or 6-membered heteroaryl ring;
- is phenyl, or a 5-membered or 6-membered heteroaryl ring;
- is phenyl, or a 5-membered or 6-membered heteroaryl ring;
- X is a bond, C1-C6alkyl, or C1-C6heteroalkyl;
- R1 is —C(═O)OR6 or —C(═O)N(R6)2;
- each R2 is independently halogen, C1-C6alkyl, or C1-C6alkoxy;
- each R3, each R4, and each R5 are each independently halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6heteroalkyl, —OR7, —N(R7)2, —CN, —C(═O)R8, —C(═O)OR7, —C(═O)N(R7)2, —NR7C(═O)R8, —NR7SO2R8, —SO2R8, or —SO2N(R7)2;
- each R6 is independently hydrogen, C1-C6alkyl, or —C1-C6alkyl-Y—R9;
- each Y is independently —O—, —S—, or —N(R10)—;
- each R7 is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, or C1-C6heteroalkyl;
- each R8 is independently C1-C6alkyl or C1-C6heteroalkyl;
- each R9 is independently hydrogen or C1-C6alkyl;
- each R10 is independently hydrogen or C1-C6alkyl;
- m is 0, 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- p is 0, 1, 2, 3, or 4;
- and
- q is 0, 1, 2, or 3;
- or a pharmaceutically acceptable salt or solvate thereof.
17 more elements
A compound having the structure of Formula (Ib):
- wherein:
- X is a bond, C1-C6alkyl, or C1-C6heteroalkyl;
- R1 is —C(═O)OR6 or —C(═O)N(R6)2;
- each R2 is independently halogen, C1-C6alkyl, or C1-C6alkoxy;
- each R3 is independently halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6heteroalkyl, —OR7, —N(R7)2, —CN, —C(═O)R8, —C(═O)OR7, —C(═O)N(R7)2, —NR7C(═O)R8, —NR7SO2R8, —SO2R8, or —SO2N(R7)2;
- R4 is hydrogen or C1-C6alkyl;
- each R5 is independently halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6heteroalkyl, —OR7, —N(R7)2, —CN, —C(═O)R8, —C(═O)OR7, —C(═O)N(R7)2, —NR7C(═O)R8, —NR7SO2R8, —SO2R8, or —SO2N(R7)2;
- each R6 is independently hydrogen, C1-C6alkyl, or —C1-C6alkyl-Y—R9;
- each Y is independently —O—, —S—, or —N(R10)—;
- each R7 is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, or C1-C6heteroalkyl;
- each R8 is independently C1-C6alkyl or C1-C6heteroalkyl;
- each R9 is independently hydrogen or C1-C6alkyl;
- each R10 is independently hydrogen or C1-C6alkyl;
- m is 0, 1, 2, 3, or 4;
- n is 0, 1, 2, 3, or 4;
- and
- q is 0, 1, 2, or 3;
- or a pharmaceutically acceptable salt or solvate thereof.
15 more elements
A compound selected from:
- or a pharmaceutically acceptable salt or solvate thereof.
A compound selected from:
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.