Compositions and methods for enhancing cancer immune checkpoint therapy
AssigneeDuke University
InventorsChuan-Yuan Li, Mengjie Hu, Min Zhou, Fang Li
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Abstract
The present disclosure provides, in part, compositions and methods for enhancing the efficacy of immune checkpoint blockade therapy in a subject. Methods for identifying subjects that are appropriate for immune checkpoint blockade therapy are also provided.
Claims26
A method of enhancing immune checkpoint inhibitor therapy in a subject suffering from a cancer, the method comprising administering to the subject a therapeutically effective amount of at least one ATM inhibitor and at least one immune checkpoint inhibitor such that the activity of the cancer immune checkpoint inhibitor is enhanced.
A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of at least one ATM inhibitor and at least one immune checkpoint inhibitor such that the cancer is treated in the subject.
A pharmaceutical composition comprising a therapeutically effective amount of at least one ATM inhibitor, a therapeutically effective amount of at least one immune checkpoint inhibitor, and a pharmaceutically acceptable carrier/excipient.
Dependencies are inferred from the claim text.