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US 2022/0175756 A1Published application
Application of combination of quinoline derivative and immunomodulator in preparation of antitumor drugs
AssigneesChongqing Pharmaceutical Industrial Research Institute Co., Ltd, Yaopharma Co., Ltd.
InventorsYang ZHANG, Zhengxia CHEN, Jian LI, Shuhui CHEN
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Abstract
Provided is an application of the combination of a quinoline derivative and an immunomodulator in preparation of antitumor drugs.
Claims25
A method of treating a tumor, comprising administering a combination of a compound of Formula (I) or a pharmaceutically acceptable salt thereof with an immunomodulator to a subject in need thereof,
- wherein,
- R1 is selected from C1-6 alkoxy optionally substituted by 1, 2 or 3 R;
- R2 is selected from —C(═O)NH2 and —C(═O)NH—C1-3 alkyl;
- ring B is selected from C3-6 cycloalkyl;
- and
- R is selected from F, Cl, Br, I, OH and NH2.
3 more elements
(canceled)
(canceled)
A composition, comprising:
- a compound represented by Formula (I)
- or an isomer or a pharmaceutically acceptable salt thereof, and
- an immunomodulator.
Dependencies are inferred from the claim text.