Opioid Receptor Ligands And Methods Of Using And Making Same

A compound, or a pharmaceutically acceptable salt thereof, having a formula of:

• or a stereoisomer thereof,
• wherein:
• A2 is selected from the group consisting of CH2, CHR5, and CR5R6;
• A4 is elected from the group consisting of CH2, CHR9, CR9R10, and a cycle of the formula C(CH2)n, where n=2-5, and when A4 is CH2, CR5R6 is not C(CH3)2, C(CH3)CH2CH3, or CHCH2(CH3)2 and when A2 is CH2, CR9R10 is not C(CH3)2, C(CH3)CH2CH3, or CHCH2(CH3)2;
• R5, R6, R9 and R10 are independently selected from the group consisting of CH3, CH2CH3, CH2F, CHF2, CF3, n-Pr, n-Bu, i-Bu, sec-Bu, i-Pr, t-Bu, and phenyl;
• B3 is selected from the group consisting of H, alkyl, branched alkyl, optionally substituted aryl, optionally substituted arylalkyl, alkoxycarbonyl, and alkylsulfonyl;
• B4 is selected from the group consisting of null, CH2, CHR19, CR19R20, and CO;
• B5 is selected from the group consisting of alkyl, branched alkyl, optionally substituted carbocycle, carbocycle-substituted alkyl, optionally substituted aryl, and optionally substituted arylalkyl;
• and
• D1 is an optionally substituted heteroaryl.