Tip60 Inhibitors and Methods of Use for Cardiovascular Disease
AssigneeThe Medical College of Wisconsin, Inc.
InventorsJohn William Lough, John Allen Auchampach
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Abstract
The present invention relates to compositions and methods of inducing cardiomyocyte proliferation by transiently contacting the cardiomyocytes with a Tip60 inhibitor. The present invention also provides methods of treating cardiac injury, myocardial infarction and methods of regenerating cardiac tissue.
Claims18
The method of inducing proliferation of adult cardiomyocytes (CMs), the method comprising:
- transiently contacting the adult CMs with an effective amount of a Tip60 inhibitor to induce proliferation of cardiomyocytes.
A method of regenerating heart tissue within a patient in need thereof, the method comprising administering an effective amount of a Tip60 inhibitor to transiently induce proliferation and regeneration of heart tissue.
A method of treating a subject with cardiac injury, the method comprising:
- administering a therapeutically effective amount of a Tip60 inhibitor to treat the cardiac injury.
(canceled)
Dependencies are inferred from the claim text.