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US 2022/0175730 A1Published application
Effects of Age-Dependent Changes in Cell Size on Endothelial Cell Growth
AssigneeThe Medical College of Wisconsin, Inc.
InventorsAkiko Mammoto, Tadamori Mammoto
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Abstract
Described herein are angiogenic stimulating compositions comprising ML141 or a derivative thereof and methods of use of said angiogenic stimulating compositions for the treatment or prevention of a disease or injury in a subject, preferably a human subject of at least 50 years of age.
Claims20
A method of stimulating angiogenesis in a subject in need thereof comprising the step of:
- administering to the subject a therapeutically effective amount of ML141 or a derivative thereof, whereby angiogenesis in the subject is stimulated.
A method of stimulating angiogenesis in a subject comprising:
- obtaining an adipose tissue sample from the subject;
- staining the adipose tissue with a stain specific for endothelial cells;
- measuring the area of the stained endothelial cells;
- and
- administering to the subject a therapeutically effective amount of ML141 or a derivative thereof when the area of the endothelial cells is at least 1.5 times larger than the area of endothelial cells from a subject less than 50 years of age, whereby angiogenesis is stimulated.
2 more elements
Dependencies are inferred from the claim text.