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US 2022/0175723 A1Published application
Methods and compositions relating to inhibition of aldehyde dehydrogenases for treatment of cancer
AssigneeThe Penn State Research Foundation
InventorsVenkata Saketh Sriram DINAVAHI, Raghavendra Gowda Chandagalu DORESWAMY, Krishne GOWDA, Shantu G. AMIN, Gavin P. ROBERTSON
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Abstract
Disclosed are compositions and methods for inhibiting aldehyde dehydrogenases. In further aspects, treatment of cancers by inhibiting aldehyde dehydrogenases with the disclosed compositions are also disclosed.
Claims28
A composition, comprising a compound of Formula I
- wherein,
- X is S or Se;
- L is a C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 cycloalkyl, C5-C6 heterocycloalkyl, or phenyl, any of which is optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, NH2, CO2H, CO2C1-C6 alkyl, halide, OH, or NO2;
- n is 0, 1, 2, or 3;
- R1 and R2 are each independently chosen from H, F, Cl, Br, I, NO2, OH, C1-C6 alkyl, C1-C6 alkoxyl, and C1-C6 haloalkyl,
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.