Degraders of fibroblast growth factor receptor 2 (fgfr2)

A bispecific compound having a structure represented by formula:

• wherein the fibroblast growth factor receptor 2 (FGFR2) targeting ligand is represented by TL-1:
• wherein
• R3 is independently halo, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted amido, carboxyl, acrylamide, optionally substituted carbocyclyl, or optionally substituted heterocyclyl;
• and
• m is an integer of 0-4, or
• the FGFR2 targeting ligand is represented by TL-2:
• wherein:
• R1 is H or optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted amido, carboxyl, acrylamide, optionally substituted carbocyclyl, or optionally substituted heterocyclyl;
• and
• n is an integer 0-4, or
• the FGFR2 targeting ligand is represented by TL-3a or TL-3b:
• or
• the FGFR2 targeting ligand is represented by TL-4:
• the degron represents a moiety that binds an E3 ubiquitin ligase, and the linker represents a moiety that covalently connects the degron and the targeting ligand, or a pharmaceutically acceptable salt or stereoisomer thereof.