Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
AssigneeAmarin Pharmaceuticals Ireland Limited
InventorMehar Manku
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Abstract
The present invention relates to, inter alia, pharmaceutical compositions comprising eicosapentaenoic acid and/or derivatives thereof and nicotinic acid, to methods of manufacturing such compositions, and to therapeutic methods for treating carious diseases and disorders.
Claims15
A pharmaceutical composition comprising nicotinic acid in an amount of not more than about 1200 mg and eicosapentaenoic acid or a derivative thereof, wherein the composition contains not more than 10%, by weight, docosahexaenoic acid, if any.
A pharmaceutical composition comprising nicotinic acid in an amount of about 1 mg to about 200 mg dispersed in about 100 mg to about 1000 mg of an oil comprising at least about 95%, by weight, eicosapentaenoic acid ethyl ester, wherein the composition contains no docosahexaenoic acid or derivative thereof and is enclosed in a capsule shell.
A method of preventing or reducing incidence or severity of niacin-induced flushing in a subject, comprising (a) providing a subject that has not yet initiated niacin therapy or a subject on niacin therapy that experiences flushing and (b) treating the subject with a pharmaceutical composition comprising at least about 95% by weight EPA or derivative thereof.
Dependencies are inferred from the claim text.