Sensitization of cancer cells to differentiation therapy with mitochondrial uncoupler niclosamide ethanolamine
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJiangbin Ye, Haowen Jiang, Yang Li
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Abstract
Methods are provided for the treatment of cancer by administering a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells, which may be provided in a combination with a retinoic acid to differentiate the cancer cells. The effect on the targeted cancer cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used. The cancer may be resistant to retinoic acid.
Claims20
A method for the treatment of cancer in an individual, the method comprising:
- contacting a population of cancer cells with a mitochondrial uncoupler in a dose effective to increase differentiation of the cancer cells.
Dependencies are inferred from the claim text.